Arthritis is is a complex family of musculoskeletal disorders with many causes, not yet fully understood, and so far there are no cures.
The most common types of arthritis are as follows:-
Osteoarthritis: It also known as mechanical abnormalities involving degradation of joints, including articular cartilage and subchondral bone. Symptoms may include joint pain, tenderness, stiffness, locking, and sometimes an effusion. It mainly occurs at the older age due to the friction of the bones at the joint.Rheumatoid arthritis: It is an autoimmune disease that results in a chronic, systemic inflammatory disorder that may affect many tissues and organs, but principally attacks flexible (synovial) joints. With lack of Synovial fluid the friction between the joints increases and as result the bones gets degenerated and damaged. without proper treatment rheumatoid arthritis can be unbearable painful.
Gout: It is the most common inflammatory joint disease in men, characterized by formation of monosodium urate (MSU) crystals in the synovial fluid of joints and in other tissues. The traditional presentation of gout involves a sudden, abrupt onset of intense joint pain. It is mostly observed in the limbs especially in feet where tumor kind of conditions occur near the great toe.
The symptoms of arthritis:
- The pain and stiffness come on quickly, whether from an injury or an unknown cause.
- The pain is accompanied by fever.
- The pain develops quickly and is associated with redness and extreme tenderness of the joint.
- You notice pain and stiffness in your arms, legs, or back after sitting for short periods or after a night's sleep
The fact that 15% of the Indian population suffers from this crippling disease is alarming and so arthritis deserves immediate attention.
In India, the cases of rheumatoid arthritis are little less than in the West but degenerative arthritis which affects the knee is more prevalent in the country with every third person above the age of 70 years suffering from it.The permanent cure or treatment of arthritis is not yet though there are surgical treatments available which can not be afforded by every patient . However further damage and degeneration of joints can be prevented with timely care and attention.
Joynt
Joynt brings joy...Back into your life
Joynt is poly herbal formulation - 100% vegetarian and devoid of any metallic content.Tulip lab pvt. ltd. has developed this formulation for effective management of the arthritis.Joynt is clinically tested herbal formulation which helps to retrieve and prevent further degradation of internal damage condition.of bones.
Every capsule of Joynt contains :-
- Boswellia serrata (Kunduru)-130 mg
- Commiphora mukul (Guggul) -100 mg
Guggulu helps remove toxins which can lead to obesity, joint pain, arthritic conditions, muscle aches, and rheumatism. It is traditionally used as a remedy for gout
- Ricinus communis (Eranda)- 60 mg
- Nycanthes arbostritis (Parijaat)- 50 mg
- Vitex Nigundo (Nirgundi)- 75 mg
- Zingifer officinales (Sunthi)- 15 mg
The regular users have admired that Joynt has given them their life back.
Proven efficacy:-
To back up with some evidential data we have conducted the clinical trial as well of the "Joynt". the change in the symptoms of the arthritis is given below:-
Effect of "Joynt" on knee joint pain assessed on VAS:
At baseline visit, the mean knee
joint pain score assessed on VAS was 51.89 + 07.85 in the arthritic patient. The mean knee joint
pain score (VAS) reduced significantly from baseline to 43.71 ± 09.06 (15.8%) after one month treatment with Joynt.The mean pain score further reduced significantly from
baseline to 38.14 ± 08.60 (26.5%) on day 60 of treatment.The mean pain score further
reduced significantly to 35.22 ± 10.71 (32.12%), 31.25 ± 11.47 (39.77%) and 24.79 ± 09.86 (52.22%) on day 90, 120
and 150 respectively. At the
end of the treatment the mean knee joint pain score reduced significantly from
baseline to 20.83 ± 08.35 (59.85%). The details are presented in below graph.
Effect of "Joynt" on mean WOMAC combined score :-
At baseline visit, the mean
WOMAC combined score among the study subjects was 35.38
± 11.21. The
mean WOMAC combined score reduced from baseline to 28.81
± 11.31 (18.56%) at the end of 30 day. The reduction in the
mean WOMAC combined score was statistically significant. The mean score further
reduced significantly from baseline to 24.88 ±09.55 (29.67%), 25.88 ± 06.92 (26.85%), and 22.44 ± 07.37 (36.57%) on day 60, 90
and 120 respectively. The mean WOMAC combined score further reduced
significantly from baseline to 21.25 ± 07.23 (39.93%) and 13.56 ± 06.89 (61.67%) on day 150 and
day 180 respectively. The
details are presented in graph.
Effect of "Joynt" on mean WOMAC pain score:
At baseline visit, the mean WOMAC
pain score among the study subjects was 08.56 ± 02.78. The mean score decreased significantly
from baseline to 06.69 ± 02.91 (17.8%)
and 05.50 ± 02.19 (35.7%) on
day 30 and 60 respectively. The statistically significant reduction in the mean
WOMAC pain score from baseline visit continued further to 06.31 ±02.30 (26.28%), 05.63 ± 02.28 (34.22%) and 04.94 ± 01.91 (42.28%) on day 90, 120
and 150. At the end of the treatment, the mean score
reduced significantly from baseline to 03.13 ± 01.96 (63.4%). The details are given in graph.
Effect of "Joynt" on mean WOMAC stiffness
score:
Initially at the beginning of
the trial, the mean WOMAC stiffness score among the study subjects was 02.81 ± 01.72. After the treatment with study drug the
mean score reduced from baseline to 02.31 ± 01.66 (17.8%) and 01.94
±01.34 (30.96%) on day 30 and 60 respectively. The reduction
in the mean score was not statistically significant. On day 90, the score increased as compared to
the score of day 60 but it reduced from baseline to 02.44 ± 01.03 (13.2%), which was
statistically insignificant. The mean score further reduced from baseline to 01.94
± 01.24 (30.96%) on day 120, the
reduction in the mean score was statistically insignificant.
The statistically
significant reduction in the mean score from baseline was observed on day 150
and at the end of the study. The score reduced significantly from baseline to 01.75
± 00.58 (37.72%) and 00.75 ± 00.77 (73.3%) on day 150 and
180 respectively. The details
are given in graph.
Effect of "Joynt" on mean
time to walk 50 feet (sec)
At baseline visit, the mean time
to walk 50 feet (sec) among study subjects was 16.31 ± 01.70. The mean time to walk 50
feet was reduced significantly to 13.69 ±01.58 (16.1%) on day 30. The
mean time reduced significantly from baseline to 13.75 ± 02.08 (15.7%), 14.44 ± 01.41 (11.46%) and 14.25 ± 01.77 (12.63%) on day 60, day
90 and day 120 respectively.
The reduction in the
mean time continued further from baseline to 13.88 ± 01.82 (14.89%) and 12.19 ± 02.04 (25.26%) on day 150 and
day 180 respectively. The reduction in the mean time to walk 50 feet (sec) was
statistically significant. The
details are given in graph.
Conclusion of the study:
Pain, stiffness of joints, reduced joint
movement and physical disability are the major clinical manifestations of
Osteoarthritis.
Six months treatment with "Joynt"
significantly decreased (p < 0.05) the mean pain (assessed on visual
analogue scale) by 59.85% in subjects suffering from osteoarthritis of the
knee. The statistically significant reduction in the mean pain (VAS)# score was
observed after 30 days it self. The pain reducing efficacy of "Joynt"
formulation was also evident from the profile of rescue medication as there was
not a single subject who needed paracetamol after 120 days onwards till the end
of the study.
Dosage: Two capsules twice a day after meals.
What is VAS?
Visual Analogue Scale:
A visual analogue scale (VAS) is a psychometric response scale which can be used in questionnaires. It is a measurement instrument for subjective characteristics or attitudes that cannot be directly measured. When responding to a VAS item, respondents specify their level of agreement to a statement by indicating a position along a continuous line between two end-points
A visual analogue scale (VAS) is a psychometric response scale which can be used in questionnaires. It is a measurement instrument for subjective characteristics or attitudes that cannot be directly measured. When responding to a VAS item, respondents specify their level of agreement to a statement by indicating a position along a continuous line between two end-points
What is WOMAC?
Western Ontario and McMaster University:
The Western Ontario and McMaster Universities Arthritis Index (WOMAC) is a widely used, proprietary set of standardized questionnaires used by health professionals to evaluate the condition of patients with osteoarthritis of the knee and hip, including pain, stiffness, and physical functioning of the joints. The WOMAC has also been used to assess back pain, rheumatoid arthritis, juvenile rheumatoid arthritis, systemic lupus erythematosus, and fibromyalgia. It can be self-administered and was developed at Western Ontario and McMaster Universities in 1982.
For more information log in to : http://joynt.co.in/
or contact at 022-66884830
or email on :
No comments:
Post a Comment